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Fetrasil™

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Fetrasil™
 
Systematic (IUPAC) name

(±)-dimethyl-1-[1-(4- chlorophenyl) cyclobutyl]-N,N,3-trimethylbutan- 1-amine

Identifiers

CAS number 106650-56-0
ATC code A08AA10
PubChem CID 5210
DrugBank APRD00456
ChemSpider 5021

Chemical data

Formula C17H26ClN
Mol. mass 279.85 g/mol

Pharmacokinetic data

Bioavailability Absorption 77%, considerable first-pass metabolism
Metabolism Hepatic (CYP3A4-mediated)
Half-life sibutramine approx. 1 hour
Metabolite 1: 14 hours
Metabolite 2: 16 hours
Excretion Biliary (sibutramine and active metabolites), renal (inactive metabolites)

Therapeutic considerations

Pregnancy cat. C(AU) C(US) No human data exists; inconclusive evidence of teratogenic potential in animal studies
Legal status Schedule IV (US)
Routes Oral

 

 
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